Ontology highlight
ABSTRACT:
SUBMITTER: Qian SW
PROVIDER: S-EPMC3587258 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Qian Shu-Wen SW Tang Yan Y Li Xi X Liu Yuan Y Zhang You-You YY Huang Hai-Yan HY Xue Rui-Dan RD Yu Hao-Yong HY Guo Liang L Gao Hui-Di HD Liu Yan Y Sun Xia X Li Yi-Ming YM Jia Wei-Ping WP Tang Qi-Qun QQ
Proceedings of the National Academy of Sciences of the United States of America 20130206 9
Expression of bone morphogenetic protein 4 (BMP4) in adipocytes of white adipose tissue (WAT) produces "white adipocytes" with characteristics of brown fat and leads to a reduction of adiposity and its metabolic complications. Although BMP4 is known to induce commitment of pluripotent stem cells to the adipocyte lineage by producing cells that possess the characteristics of preadipocytes, its effects on the mature white adipocyte phenotype and function were unknown. Forced expression of a BMP4 t ...[more]