Ontology highlight
ABSTRACT:
SUBMITTER: Goodyer WR
PROVIDER: S-EPMC3587727 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Goodyer William R WR Gu Xueying X Liu Yinghua Y Bottino Rita R Crabtree Gerald R GR Kim Seung K SK
Developmental cell 20120701 1
Little is known about the mechanisms governing neonatal growth and maturation of organs. Here we demonstrate that calcineurin/Nuclear Factor of Activated T cells (Cn/NFAT) signaling regulates neonatal pancreatic development in mouse and human islets. Inactivation of calcineurin b1 (Cnb1) in mouse islets impaired dense core granule biogenesis, decreased insulin secretion, and reduced cell proliferation and mass, culminating in lethal diabetes. Pancreatic β cells lacking Cnb1 failed to express gen ...[more]