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MTOR inhibitors in advanced renal cell carcinoma.

ABSTRACT: Better understanding of the molecular biology of renal cell carcinoma (RCC) has led to the development of several targeted anti-cancer agents, several of which have since received approval for treatment of advanced disease. Two of these, the intravenous agent temsirolimus and the oral everolimus, exhibit antitumor effects through inhibition of the mammalian target of rapamycin (mTOR) pathway. This article reviews their mechanisms of action in the context of the current understanding of RCC pathophysiology, the clinical data leading to their approval, class-specific toxicities, potential molecular mechanisms behind treatment resistance and novel treatment approaches for RCC that incorporate mTOR blockade.

SUBMITTER: Voss MH

PROVIDER: S-EPMC3587783 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature

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mTOR inhibitors in advanced renal cell carcinoma.

Voss Martin H MH Molina Ana M AM Motzer Robert J RJ

Hematology/oncology clinics of North America 20110801 4

Better understanding of the molecular biology of renal cell carcinoma (RCC) has led to the development of several targeted anti-cancer agents, several of which have since received approval for treatment of advanced disease. Two of these, the intravenous agent temsirolimus and the oral everolimus, exhibit antitumor effects through inhibition of the mammalian target of rapamycin (mTOR) pathway. This article reviews their mechanisms of action in the context of the current understanding of RCC patho ...[more]

PMID: 21763970

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