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Reversing chemoresistance of malignant glioma stem cells using gold nanoparticles.

ABSTRACT: The low rate of survival for patients diagnosed with glioblastoma may be attributed to the existence of a subpopulation of cancer stem cells. These stem cells have certain properties that enable them to resist chemotherapeutic agents and ionizing radiation. Herein, we show that temozolomide-loaded gold nanostructures are efficient in reducing chemoresistance and destroy 82.7% of cancer stem cells compared with a 42% destruction rate using temozolomide alone. Measurements of in vitro cytotoxicity and apoptosis indicate that combination with gold facilitated the ability of temozolomide, an alkylating drug, to alter the resistance of these cancer stem cells, suggesting a new chemotherapy strategy for patients diagnosed with inoperable recurrent malignant glioma.

SUBMITTER: Orza A

PROVIDER: S-EPMC3589121 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Reversing chemoresistance of malignant glioma stem cells using gold nanoparticles.

Orza Anamaria A Soriţău Olga O Tomuleasa Ciprian C Olenic Liliana L Florea Adrian A Pana Ovidiu O Bratu Ioan I Pall Emoke E Florian Stefan S Casciano Dan D Biris Alexandru S AS

International journal of nanomedicine 20130301

The low rate of survival for patients diagnosed with glioblastoma may be attributed to the existence of a subpopulation of cancer stem cells. These stem cells have certain properties that enable them to resist chemotherapeutic agents and ionizing radiation. Herein, we show that temozolomide-loaded gold nanostructures are efficient in reducing chemoresistance and destroy 82.7% of cancer stem cells compared with a 42% destruction rate using temozolomide alone. Measurements of in vitro cytotoxicity ...[more]

PMID: 23467447

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