Ontology highlight
ABSTRACT:
SUBMITTER: Kang TH
PROVIDER: S-EPMC3589158 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Kang Tae Heung TH Ma Barbara B Wang Connie C Wu T-C TC Hung Chien-Fu CF
Molecular therapy : the journal of the American Society of Gene Therapy 20121127 3
The potency of immunotherapies targeting endogenous tumor antigens is hindered by immune tolerance. We created a therapeutic agent comprised of a tumor-homing module fused to a functional domain capable of selectively rendering tumor cells sensitive to foreign antigen-specific CD8(+) T cell-mediated immune attack, and thereby, circumventing concerns for immune tolerance. The tumor-homing module is comprised of a single-chain variable fragment (scFv) that specifically binds to mesothelin (Meso), ...[more]