Ontology highlight
ABSTRACT:
SUBMITTER: Hogarth CA
PROVIDER: S-EPMC3589231 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Hogarth Cathryn A CA Evanoff Ryan R Mitchell Debra D Kent Travis T Small Christopher C Amory John K JK Griswold Michael D MD
Biology of reproduction 20130214 2
The BDADs (bis-[dichloroacetyl]-diamines) are compounds that can inhibit spermatogenesis via blocking the metabolism of vitamin A. We utilized one specific BDAD, WIN 18,446, to manipulate the endogenous production of retinoic acid (RA) in the testis to further investigate the action of this compound on mammalian sperm production. Transient treatment of adult male mice with WIN 18,446 blocked spermatogonial differentiation and induced significant changes in the cycle of the seminiferous epitheliu ...[more]