Ontology highlight
ABSTRACT:
SUBMITTER: Noelker C
PROVIDER: S-EPMC3589722 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Scientific reports 20130101
In mammalians, toll-like receptors (TLR) signal-transduction pathways induce the expression of a variety of immune-response genes, including inflammatory cytokines. It is therefore plausible to assume that TLRs are mediators in glial cells triggering the release of cytokines that ultimately kill DA neurons in the substantia nigra in Parkinson disease (PD). Accordingly, recent data indicate that TLR4 is up-regulated by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment in a mouse model ...[more]