Dataset Information

Mesoporous single-crystal CoSn(OH)6 hollow structures with multilevel interiors.

ABSTRACT: Hollow nanostructures represent a unique class of functional nanomaterials with many applications. In this work, a one-pot and unusual "pumpkin-carving" protocol is demonstrated for engineering mesoporous single-crystal hollow structures with multilevel interiors. Single-crystal CoSn(OH)6 nanoboxes with uniform size and porous shell are synthesized by fast growth of CoSn(OH)6 nanocubes and kinetically-controlled etching in alkaline medium. Detailed investigation on reaction course suggests that the formation of a passivation layer of Co(III) species around the liquid-solid interface is critical for the unusual hollowing process. With reasonable understanding on the mechanism involved, this approach shows high versatility for the synthesis of CoSn(OH)6 hollow architectures with a higher order of interior complexity, such as yolk-shell particles and multishelled nanoboxes. The obtained CoSn(OH)6 hollow nanostructures can be easily converted to hollow nanostructures of tin-based ternary metal oxides with excellent photocatalytic and electrochemical properties.

SUBMITTER: Wang Z

PROVIDER: S-EPMC3589726 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Mesoporous single-crystal CoSn(OH)6 hollow structures with multilevel interiors.

Wang Zhiyu Z Wang Zichen Z Wu Haobin H Lou Xiong Wen David XW

Scientific reports 20130101

Hollow nanostructures represent a unique class of functional nanomaterials with many applications. In this work, a one-pot and unusual "pumpkin-carving" protocol is demonstrated for engineering mesoporous single-crystal hollow structures with multilevel interiors. Single-crystal CoSn(OH)6 nanoboxes with uniform size and porous shell are synthesized by fast growth of CoSn(OH)6 nanocubes and kinetically-controlled etching in alkaline medium. Detailed investigation on reaction course suggests that ...[more]

PMID: 23462692

Similar Datasets

Project description:Tunable glutathione (GSH)-sensitive hollow mesoporous silica nanoparticles (HMSiO2 NPs) were developed using a structural difference-based selective etching strategy. These organosilica hollow nanoparticles contained disulfide linkages (S-S) in the outer shell which were degraded by GSH. The particles were compared with their nonGSH-sensitive tetraethyl orthosilicate (TEOS) HMSiO2 counterparts in terms of their synthesis method, characterization, doxorubicin (DOX) release profile, and in vitro cytotoxicity in MCF-7 breast cancer cells. Transmission electron microscopy (TEM) of the particles indicated that the fabricated HMSiO2 NPs had an average diameter of 130?±?5?nm. Thermogravimetric analysis (TGA) revealed that GSH-sensitive particles had approximately 5.3% more weight loss than TEOS HMSiO2 NPs. Zeta potential of these redox-responsive particles was -23?±?1?mV at pH?6 in deionized (DI) water. Nitrogen adsorption-desorption isotherm revealed that the surface area of the hollow mesoporous nanoreservoirs was roughly 446?±?6?m2?g-1 and the average diameter of the pores was 2.3?±?0.5?nm. TEM images suggest that the nanoparticles started to lose mass integrity from Day 1. The particles showed a high loading capacity for DOX (8.9?±?0.5%) as a model drug, due to the large voids existing in the hollow structures. Approximately 58% of the incorporated DOX released within 14?days in phosphate buffered saline (PBS) at pH?6 and in the presence of 10?mM of GSH, mimicking intracellular tumor microenvironment while release from TEOS HMSiO2 NPs was only c.a. 18%. The uptake of these hollow nanospheres by MCF-7 cells and RAW 264.7 macrophages was evaluated using TEM and confocal microscopy. The nanospheres were shown to accumulate in the endolysosomal compartments after incubation for 24?h with the maximum uptake of c.a. 2.1?±?0.3% and 5.2?±?0.4%, respectively. Cytotoxicity of the nanospheres was investigated using CCK-8 assay. Results indicate that intact hollow particles (both GSH-sensitive and TEOS HMSiO2 NPs) were nontoxic to MCF-7 cells after incubation for 24?h within the concentration range of 0-1000??g?ml-1. DOX-loaded GSH-sensitive nanospheres containing 6??g?ml-1 of DOX killed c.a. 51% of MCF-7 cells after 24?h while TEOS HMSiO2 NPs killed c.a. 20% with the difference being statistically significant. Finally, cytotoxicity data in RAW 264.7 macrophages and NIH 3?T3 fibroblasts shows that intact GSH-sensitive HMSiO2 NPs did not show any toxic effects on these cells with the concentrations equal or <125??g?ml-1.

Dataset Information

Mesoporous single-crystal CoSn(OH)6 hollow structures with multilevel interiors.

Publications

Mesoporous single-crystal CoSn(OH)6 hollow structures with multilevel interiors.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets