Ontology highlight
ABSTRACT:
SUBMITTER: Johnson SJ
PROVIDER: S-EPMC3590235 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Johnson Sean J SJ Jackson Ryan N RN
RNA biology 20120920 1
Ski2-like RNA helicases are large multidomain proteins involved in a variety of RNA processing and degradation events. Recent structures of Mtr4, Ski2 and Brr2 provide our first view of these intricate helicases. Here we review these structures, which reveal a conserved ring-like architecture that extends beyond the canonical RecA domains to include a winged helix and ratchet domain. Comparison of apo- and RNA-bound Mtr4 structures suggests a role for the winged helix domain as a molecular hub t ...[more]