Ontology highlight
ABSTRACT:
SUBMITTER: Lapierre LR
PROVIDER: S-EPMC3590250 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Lapierre Louis R LR Silvestrini Melissa J MJ Nuñez Lizbeth L Ames Kristina K Wong Sara S Le Thuc T TT Hansen Malene M Meléndez Alicia A
Autophagy 20130115 3
Autophagy is a cellular catabolic process in which various cytosolic components are degraded. For example, autophagy can mediate lipolysis of neutral lipid droplets. In contrast, we here report that autophagy is required to facilitate normal levels of neutral lipids in C. elegans. Specifically, by using multiple methods to detect lipid droplets including CARS microscopy, we observed that mutants in the gene bec- 1 (VPS30/ATG6/BECN1), a key regulator of autophagy, failed to store substantial neut ...[more]