Ontology highlight
ABSTRACT:
SUBMITTER: Park CW
PROVIDER: S-EPMC3590255 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Park Chang Wook CW Hong Sun Mi SM Kim Eung-Sam ES Kwon Jung Hee JH Kim Kyong-Tai KT Nam Hong Gil HG Choi Kwan Yong KY
Autophagy 20130104 3
BNIP3 (BCL2/adenovirus E1B 19 kDa interacting protein 3) is an atypical BH3-only protein that is induced by hypoxia-inducible factor 1 (HIF1) under hypoxia. BNIP3 is primarily regulated at the transcriptional level. However, little is known about the underlying mechanism of BNIP3 degradation. In this study, we found that BNIP3 was downregulated when hypoxia was accompanied by amino acid starvation. The BNIP3 downregulation did not occur at the transcription level and was independent of HIF1A. BN ...[more]