Ontology highlight
ABSTRACT:
SUBMITTER: Buheitel J
PROVIDER: S-EPMC3590994 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Buheitel Johannes J Stemmann Olaf O
The EMBO journal 20130129 5
Faithful transmission of chromosomes during eukaryotic cell division requires sister chromatids to be paired from their generation in S phase until their separation in M phase. Cohesion is mediated by the cohesin complex, whose Smc1, Smc3 and Scc1 subunits form a tripartite ring that entraps both DNA double strands. Whereas centromeric cohesin is removed in late metaphase by Scc1 cleavage, metazoan cohesin at chromosome arms is displaced already in prophase by proteolysis-independent signalling. ...[more]