Ontology highlight
ABSTRACT:
SUBMITTER: Katzemich A
PROVIDER: S-EPMC3591300 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Katzemich Anja A Liao Kuo An KA Czerniecki Stefan S Schöck Frieder F
PLoS genetics 20130307 3
The Drosophila Alp/Enigma family protein Zasp52 localizes to myotendinous junctions and Z-discs. It is required for terminal muscle differentiation and muscle attachment. Its vertebrate ortholog ZASP/Cypher also localizes to Z-discs, interacts with α-actinin through its PDZ domain, and is involved in Z-disc maintenance. Human mutations in ZASP cause myopathies and cardiomyopathies. Here we show that Drosophila Zasp52 is one of the earliest markers of Z-disc assembly, and we use a Zasp52-GFP fusi ...[more]