Ontology highlight
ABSTRACT:
SUBMITTER: Velazquez-Delgado EM
PROVIDER: S-EPMC3591518 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Velázquez-Delgado Elih M EM Hardy Jeanne A JA
Structure (London, England : 1993) 20120403 4
Caspases, a family of apoptotic proteases, are increasingly recognized as being extensively phosphorylated, usually leading to inactivation. To date, no structural mechanism for phosphorylation-based caspase inactivation is available, although this information may be key to achieving caspase-specific inhibition. Caspase-6 has recently been implicated in neurodegenerative conditions including Huntington's and Alzheimer's diseases. A full understanding of caspase-6 regulation is crucial to caspase ...[more]