Ontology highlight
ABSTRACT:
SUBMITTER: Lee JJ
PROVIDER: S-EPMC3591610 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Lee Jae-Jin JJ Park Joon Kyu JK Jeong Jaeho J Jeon Hyesung H Yoon Jong-Bok JB Kim Eunice EunKyeong EE Lee Kong-Joo KJ
The Journal of biological chemistry 20130104 10
Fas-associated factor 1 (FAF1) is a ubiquitin receptor containing multiple ubiquitin-related domains including ubiquitin-associated (UBA), ubiquitin-like (UBL) 1, UBL2, and ubiquitin regulatory X (UBX). We previously showed that N-terminal UBA domain recognizes Lys(48)-ubiquitin linkage to recruit polyubiquitinated proteins and that a C-terminal UBX domain interacts with valosin-containing protein (VCP). This study shows that FAF1 interacts only with VCP complexed with Npl4-Ufd1 heterodimer, a r ...[more]