Ontology highlight
ABSTRACT:
SUBMITTER: Ziesche E
PROVIDER: S-EPMC3592411 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Ziesché Elisabeth E Kettner-Buhrow Daniela D Weber Axel A Wittwer Tobias T Jurida Liane L Soelch Johanna J Müller Helmut H Newel Doris D Kronich Petra P Schneider Heike H Dittrich-Breiholz Oliver O Bhaskara Srividya S Hiebert Scott W SW Hottiger Michael O MO Li Haiying H Burstein Ezra E Schmitz M Lienhard ML Kracht Michael M
Nucleic acids research 20121019 1
Histone deacetylase (HDAC) 3, as a cofactor in co-repressor complexes containing silencing mediator for retinoid or thyroid-hormone receptors (SMRT) and nuclear receptor co-repressor (N-CoR), has been shown to repress gene transcription in a variety of contexts. Here, we reveal a novel role for HDAC3 as a positive regulator of IL-1-induced gene expression. Various experimental approaches involving RNAi-mediated knockdown, conditional gene deletion or small molecule inhibitors indicate a positive ...[more]