Troponin T nuclear localization and its role in aging skeletal muscle.
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ABSTRACT:
SUBMITTER: Zhang T
PROVIDER: S-EPMC3592954 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Publications
Troponin T nuclear localization and its role in aging skeletal muscle.
Zhang Tan T Birbrair Alexander A Wang Zhong-Min ZM Taylor Jackson J Messi María Laura ML Delbono Osvaldo O
Age (Dordrecht, Netherlands) 20111222 2
Troponin T (TnT) is known to mediate the interaction between Tn complex and tropomyosin (Tm), which is essential for calcium-activated striated muscle contraction. This regulatory function takes place in the myoplasm, where TnT binds Tm. However, recent findings of troponin I and Tm nuclear translocation in Drosophila and mammalian cells imply other roles for the Tn-Tm complex. We hypothesized that TnT plays a nonclassical role through nuclear translocation. Immunoblotting with different antibod ...[more]
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