Dataset Information

Individual patient data meta-analysis shows no association between the SNP rs1800469 in TGFB and late radiotherapy toxicity.

ABSTRACT:

Background and purpose

Reported associations between risk of radiation-induced normal tissue injury and single nucleotide polymorphisms (SNPs) in TGFB1, encoding the pro-fibrotic cytokine transforming growth factor-beta 1 (TGF-?1), remain controversial. To overcome publication bias, the international Radiogenomics Consortium collected and analysed individual patient level data from both published and unpublished studies.

Materials and methods

TGFB1 SNP rs1800469 c.-1347T>C (previously known as C-509T) genotype, treatment-related data, and clinically-assessed fibrosis (measured at least 2years after therapy) were available in 2782 participants from 11 cohorts. All received adjuvant breast radiotherapy. Associations between late fibrosis or overall toxicity, reported by STAT (Standardised Total Average Toxicity) score, and rs1800469 genotype were assessed.

Results

No statistically significant associations between either fibrosis or overall toxicity and rs1800469 genotype were observed with univariate or multivariate regression analysis. The multivariate odds ratio (OR), obtained from meta-analysis, for an increase in late fibrosis grade with each additional rare allele of rs1800469 was 0.98 (95% Confidence Interval (CI) 0.85-1.11). This CI is sufficiently narrow to rule out any clinically relevant effect on toxicity risk in carriers vs. non-carriers with a high probability.

Conclusion

This meta-analysis has not confirmed previous reports of association between fibrosis or overall toxicity and rs1800469 genotype in breast cancer patients. It has demonstrated successful collaboration within the Radiogenomics Consortium.

SUBMITTER: Barnett GC

PROVIDER: S-EPMC3593101 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature

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Publications

Individual patient data meta-analysis shows no association between the SNP rs1800469 in TGFB and late radiotherapy toxicity.

Barnett Gillian C GC Elliott Rebecca M RM Alsner Jan J Andreassen Christian N CN Abdelhay Osama O Burnet Neil G NG Chang-Claude Jenny J Coles Charlotte E CE Gutiérrez-Enríquez Sara S Fuentes-Raspall Maria J MJ Alonso-Muñoz Maria C MC Kerns Sarah S Raabe Annette A Symonds R Paul RP Seibold Petra P Talbot Chris J CJ Wenz Frederik F Wilkinson Jennifer J Yarnold John J Dunning Alison M AM Rosenstein Barry S BS West Catharine M L CM Bentzen Søren M SM

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20121128 3

<h4>Background and purpose</h4>Reported associations between risk of radiation-induced normal tissue injury and single nucleotide polymorphisms (SNPs) in TGFB1, encoding the pro-fibrotic cytokine transforming growth factor-beta 1 (TGF-β1), remain controversial. To overcome publication bias, the international Radiogenomics Consortium collected and analysed individual patient level data from both published and unpublished studies.<h4>Materials and methods</h4>TGFB1 SNP rs1800469 c.-1347T>C (previo ...[more]

PMID: 23199655

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Dataset Information

Individual patient data meta-analysis shows no association between the SNP rs1800469 in TGFB and late radiotherapy toxicity.

Background and purpose

Materials and methods

Results

Conclusion

Publications

Individual patient data meta-analysis shows no association between the SNP rs1800469 in TGFB and late radiotherapy toxicity.

Similar Datasets

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