Ontology highlight
ABSTRACT:
SUBMITTER: Yang J
PROVIDER: S-EPMC3593158 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Yang Jian J Ferreira Teresa T Morris Andrew P AP Medland Sarah E SE Madden Pamela A F PA Heath Andrew C AC Martin Nicholas G NG Montgomery Grant W GW Weedon Michael N MN Loos Ruth J RJ Frayling Timothy M TM McCarthy Mark I MI Hirschhorn Joel N JN Goddard Michael E ME Visscher Peter M PM
Nature genetics 20120318 4
We present an approximate conditional and joint association analysis that can use summary-level statistics from a meta-analysis of genome-wide association studies (GWAS) and estimated linkage disequilibrium (LD) from a reference sample with individual-level genotype data. Using this method, we analyzed meta-analysis summary data from the GIANT Consortium for height and body mass index (BMI), with the LD structure estimated from genotype data in two independent cohorts. We identified 36 loci with ...[more]