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The "what" and "when" of self-initiated movements.

ABSTRACT: The ability to generate intentional behavior is undeniably at the core of what makes us acting subjects. Intentional actions consist of at least 2 components (Brass M, Haggard P. 2008. The what, when, whether model of intentional action. Neuroscientist. 14:319-325.): choosing an appropriate behavior (what) and selecting the moment of execution (when). The aim of this study was to identify differing and overlapping neural networks underlying the "what" and "when" of intentional movement initiation. While scanned with functional magnetic resonance imaging, 35 healthy subjects performed self-initiated and reactive, that is, internally and externally triggered movements of the right or left index finger in 3 experimental conditions: 1) "Free Choice" (free timing: when/choice of hand: what), 2) "Timed Choice" (external timing/choice of hand: what), and 3) "No Choice" (external timing/cued hand). The what-component specifically employed the presupplementary motor area (SMA) and dorsal premotor cortex bilaterally. The when-network consisted of superior SMA together with insula and Area 44 bilaterally as well as bilateral anterior putamen, globus pallidus, and left cerebellum subcortically. These 2 components recruited different networks, pointing to a partially distinct neuronal realization of the relating functions. Finally, the more intentional components were involved, the higher was activity in the anterior midcingulate cortex, which highlighted its role in intentional initiation of behavior.

SUBMITTER: Hoffstaedter F

PROVIDER: S-EPMC3593700 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature

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The "what" and "when" of self-initiated movements.

Hoffstaedter Felix F Grefkes Christian C Zilles Karl K Zilles Karl K Eickhoff Simon B SB

Cerebral cortex (New York, N.Y. : 1991) 20120313 3

The ability to generate intentional behavior is undeniably at the core of what makes us acting subjects. Intentional actions consist of at least 2 components (Brass M, Haggard P. 2008. The what, when, whether model of intentional action. Neuroscientist. 14:319-325.): choosing an appropriate behavior (what) and selecting the moment of execution (when). The aim of this study was to identify differing and overlapping neural networks underlying the "what" and "when" of intentional movement initiatio ...[more]

PMID: 22414772

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Project description:Ample research in visual working memory (VWM) has demonstrated that the memorized items are maintained in integrated spatial configurations, even when the spatial context is task irrelevant. These insights were obtained in studies in which participants were provided with the information they memorized. However, the encoding of provided information is only one aspect of memory. In everyday life, individuals often construct their own memory representations, an aspect of memory we have previously termed self-initiated (SI) working memory. In this study, we employed a SI VWM task in which participants selected the visual targets they memorized. The spatial locations of the targets were task irrelevant. Nevertheless, we were interested to see whether participants would construct spatially structured memory representations, which would suggest that they intended to maintain the visual targets as integrated spatial configurations. The results of two experiments demonstrated that participants constructed spatially structured configurations relative to random displays. Specifically, participants selected visual targets in close spatial proximity and constructed spatial sequences with short distances and fewer path crossings. When asked to construct configurations for a hypothetical competitor in a memory contest, participants disrupted the spatial structure by selecting visual targets that were further apart and by increasing the distances between them, which suggests that these characteristics were under their control. At the end of each experiment, participants provided verbal descriptions of the strategies they used to construct the memory displays. While the spatial structure of the SI memory representations was robust, it was absent from the participants' explicit descriptions, which focused on non-spatial strategies. Participants reported selecting items based, most frequently, on semantic categories and visual features. Taken together, these results demonstrated that participants had access to the metacognitive knowledge on the spatial structure of VWM representations, knowledge they manipulated to construct memory representations that enhanced or disrupted memory performance. While having a profound impact on behavior, this metacognitive knowledge on spatial structure remained implicit, as it was absent from the participants' verbal reports. Viewed from a larger perspective, this study explores how individuals interact with the world by actively structuring their surroundings to maximize cognitive performance.

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The "what" and "when" of self-initiated movements.

Publications

The "what" and "when" of self-initiated movements.

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