Transcriptional Modulation of the ERK1/2 MAPK and NF-κB Pathways in Human Urothelial Cells After Trivalent Arsenical Exposure: Implications for Urinary Bladder Cancer.

ABSTRACT: Chronic exposure to drinking water contaminated with inorganic arsenic (iAs) is associated with an increased risk of urinary bladder (UB) cancers in humans. The exact role of specific iAs metabolite(s) in As-mediated carcinogenesis remains largely unknown. Experimental evidence suggests that trivalent arsenicals, namely arsenite (iAs^III) and two of its metabolites, monomethylarsonous acid (MMA^III) and dimethylarsinous acid (DMA^III), are possible proximate UB carcinogens. Here, we used a transcriptomics approach to examine perturbed molecular pathways in a human urothelial cell line (UROtsa) after short-term exposure to iAs^III, MMA^III and DMA^III. Molecular pathways containing genes that encode proteins implicated in UB cancer

SUBMITTER: Bailey KA 

PROVIDER: S-EPMC3593739 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature