Dataset Information

Fruit and vegetable intake and risk of breast cancer by hormone receptor status.

ABSTRACT:

Background

Estrogen receptor-negative (ER(-)) breast cancer has few known or modifiable risk factors. Because ER(-) tumors account for only 15% to 20% of breast cancers, large pooled analyses are necessary to evaluate precisely the suspected inverse association between fruit and vegetable intake and risk of ER(-) breast cancer.

Methods

Among 993 466 women followed for 11 to 20 years in 20 cohort studies, we documented 19 869 estrogen receptor positive (ER(+)) and 4821 ER(-) breast cancers. We calculated study-specific multivariable relative risks (RRs) and 95% confidence intervals (CIs) using Cox proportional hazards regression analyses and then combined them using a random-effects model. All statistical tests were two-sided.

Results

Total fruit and vegetable intake was statistically significantly inversely associated with risk of ER(-) breast cancer but not with risk of breast cancer overall or of ER(+) tumors. The inverse association for ER(-) tumors was observed primarily for vegetable consumption. The pooled relative risks comparing the highest vs lowest quintile of total vegetable consumption were 0.82 (95% CI = 0.74 to 0.90) for ER(-) breast cancer and 1.04 (95% CI = 0.97 to 1.11) for ER(+) breast cancer (P (common-effects) by ER status < .001). Total fruit consumption was non-statistically significantly associated with risk of ER(-) breast cancer (pooled multivariable RR comparing the highest vs lowest quintile = 0.94, 95% CI = 0.85 to 1.04).

Conclusions

We observed no association between total fruit and vegetable intake and risk of overall breast cancer. However, vegetable consumption was inversely associated with risk of ER(-) breast cancer in our large pooled analyses.

SUBMITTER: Jung S

PROVIDER: S-EPMC3593764 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature

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Publications

Fruit and vegetable intake and risk of breast cancer by hormone receptor status.

Jung Seungyoun S Spiegelman Donna D Baglietto Laura L Bernstein Leslie L Boggs Deborah A DA van den Brandt Piet A PA Buring Julie E JE Cerhan James R JR Gaudet Mia M MM Giles Graham G GG Goodman Gary G Hakansson Niclas N Hankinson Susan E SE Helzlsouer Kathy K Horn-Ross Pamela L PL Inoue Manami M Krogh Vittorio V Lof Marie M McCullough Marjorie L ML Miller Anthony B AB Neuhouser Marian L ML Palmer Julie R JR Park Yikyung Y Robien Kim K Rohan Thomas E TE Scarmo Stephanie S Schairer Catherine C Schouten Leo J LJ Shikany James M JM Sieri Sabina S Tsugane Schoichiro S Visvanathan Kala K Weiderpass Elisabete E Willett Walter C WC Wolk Alicja A Zeleniuch-Jacquotte Anne A Zhang Shumin M SM Zhang Xuehong X Ziegler Regina G RG Smith-Warner Stephanie A SA

Journal of the National Cancer Institute 20130124 3

<h4>Background</h4>Estrogen receptor-negative (ER(-)) breast cancer has few known or modifiable risk factors. Because ER(-) tumors account for only 15% to 20% of breast cancers, large pooled analyses are necessary to evaluate precisely the suspected inverse association between fruit and vegetable intake and risk of ER(-) breast cancer.<h4>Methods</h4>Among 993 466 women followed for 11 to 20 years in 20 cohort studies, we documented 19 869 estrogen receptor positive (ER(+)) and 4821 ER(-) breast ...[more]

PMID: 23349252

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Dataset Information

Fruit and vegetable intake and risk of breast cancer by hormone receptor status.

Background

Methods

Results

Conclusions

Publications

Fruit and vegetable intake and risk of breast cancer by hormone receptor status.

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