Ontology highlight
ABSTRACT:
SUBMITTER: Minnihan EC
PROVIDER: S-EPMC3593893 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Minnihan Ellen C EC Ando Nozomi N Brignole Edward J EJ Olshansky Lisa L Chittuluru Johnathan J Asturias Francisco J FJ Drennan Catherine L CL Nocera Daniel G DG Stubbe Joanne J
Proceedings of the National Academy of Sciences of the United States of America 20130219 10
Ribonucleotide reductase (RNR) catalyzes the conversion of nucleoside diphosphates to deoxynucleoside diphosphates (dNDPs). The Escherichia coli class Ia RNR uses a mechanism of radical propagation by which a cysteine in the active site of the RNR large (α2) subunit is transiently oxidized by a stable tyrosyl radical (Y•) in the RNR small (β2) subunit over a 35-Å pathway of redox-active amino acids: Y122• ↔ [W48?] ↔ Y356 in β2 to Y731 ↔ Y730 ↔ C439 in α2. When 3-aminotyrosine (NH2Y) is incorpora ...[more]