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Novel Bruton's tyrosine kinase inhibitors currently in development.


ABSTRACT: Bruton's tyrosine kinase (Btk) is intimately involved in multiple signal-transduction pathways regulating survival, activation, proliferation, and differentiation of B-lineage lymphoid cells. Btk is overexpressed and constitutively active in several B-lineage lymphoid malignancies. Btk has emerged as a new antiapoptotic molecular target for treatment of B-lineage leukemias and lymphomas. Preclinical and early clinical results indicate that Btk inhibitors may be useful in the treatment of leukemias and lymphomas.

SUBMITTER: D'Cruz OJ 

PROVIDER: S-EPMC3594038 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Novel Bruton's tyrosine kinase inhibitors currently in development.

D'Cruz Osmond J OJ   Uckun Fatih M FM  

OncoTargets and therapy 20130306


Bruton's tyrosine kinase (Btk) is intimately involved in multiple signal-transduction pathways regulating survival, activation, proliferation, and differentiation of B-lineage lymphoid cells. Btk is overexpressed and constitutively active in several B-lineage lymphoid malignancies. Btk has emerged as a new antiapoptotic molecular target for treatment of B-lineage leukemias and lymphomas. Preclinical and early clinical results indicate that Btk inhibitors may be useful in the treatment of leukemi  ...[more]

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