Ontology highlight
ABSTRACT:
SUBMITTER: Stavropoulou AV
PROVIDER: S-EPMC3594241 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Stavropoulou Alexandra V AV Fostira Florentia F Pertesi Maroulio M Tsitlaidou Marianthi M Voutsinas Gerassimos E GE Triantafyllidou Olga O Bamias Aristotelis A Dimopoulos Meletios A MA Timotheadou Eleni E Pectasides Dimitrios D Christodoulou Christos C Klouvas George G Papadimitriou Christos C Makatsoris Thomas T Pentheroudakis George G Aravantinos Gerasimos G Karydakis Vassilis V Yannoukakos Drakoulis D Fountzilas George G Konstantopoulou Irene I
PloS one 20130311 3
Germline mutations in the BRCA1 and BRCA2 genes contribute to approximately 18% of hereditary ovarian cancers conferring an estimated lifetime risk from 15% to 50%. A variable incidence of mutations has been reported for these genes in ovarian cancer cases from different populations. In Greece, six mutations in BRCA1 account for 63% of all mutations detected in both BRCA1 and BRCA2 genes. This study aimed to determine the prevalence of BRCA1 mutations in a Greek cohort of 106 familial ovarian ca ...[more]