Ontology highlight
ABSTRACT:
SUBMITTER: Moumen A
PROVIDER: S-EPMC3594270 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Moumen Abdeladim A Magill Christine C Dry Katherine L KL Jackson Stephen P SP
Cell cycle (Georgetown, Tex.) 20130123 4
Previous work has established that heterogeneous nuclear ribonucleoprotein K (hnRNP K) is stabilized in an ATM-dependent manner in response to DNA damage and acts as a cofactor for p53-mediated transcription. Here, we show that in response to DNA damage caused by ionizing radiation, hnRNP K is phosphorylated in an ATM-dependent manner. Furthermore, our data indicate that ATM-dependent hnRNP K phosphorylation is required for its stabilization and its function as a p53 transcriptional cofactor in ...[more]