Ontology highlight
ABSTRACT:
SUBMITTER: Tzoneva G
PROVIDER: S-EPMC3594483 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Nature medicine 20130203 3
Acute lymphoblastic leukemia (ALL) is an aggressive hematological tumor resulting from the malignant transformation of lymphoid progenitors. Despite intensive chemotherapy, 20% of pediatric patients and over 50% of adult patients with ALL do not achieve a complete remission or relapse after intensified chemotherapy, making disease relapse and resistance to therapy the most substantial challenge in the treatment of this disease. Using whole-exome sequencing, we identify mutations in the cytosolic ...[more]