Ontology highlight
ABSTRACT:
SUBMITTER: Mo W
PROVIDER: S-EPMC3594500 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Mo Wei W Chen Jian J Patel Amish A Zhang Liang L Chau Vincent V Li Yanjiao Y Cho Woosung W Lim Kyun K Xu Jing J Lazar Alexander J AJ Creighton Chad J CJ Bolshakov Svetlana S McKay Renée M RM Lev Dina D Le Lu Q LQ Parada Luis F LF
Cell 20130221 5
Malignant peripheral nerve sheath tumors (MPNSTs) are soft tissue sarcomas that arise in connective tissue surrounding peripheral nerves. They occur sporadically in a subset of patients with neurofibromatosis type 1 (NF1). MPNSTs are highly aggressive, therapeutically resistant, and typically fatal. Using comparative transcriptome analysis, we identified CXCR4, a G-protein-coupled receptor, as highly expressed in mouse models of NF1-deficient MPNSTs, but not in nontransformed precursor cells. Th ...[more]