Induction of mesenchymal stem cell chondrogenesis by polyacrylate substrates.
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ABSTRACT:
SUBMITTER: Glennon-Alty L
PROVIDER: S-EPMC3594746 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Publications
Induction of mesenchymal stem cell chondrogenesis by polyacrylate substrates.
Glennon-Alty Laurence L Williams Rachel R Dixon Simon S Murray Patricia P
Acta biomaterialia 20121211 4
Mesenchymal stem cells (MSCs) can generate chondrocytes in vitro, but typically need to be cultured as aggregates in the presence of transforming growth factor beta (TGF-β), which makes scale-up difficult. Here we investigated if polyacrylate substrates modelled on the functional group composition and distribution of the Arg-Gly-Asp (RGD) integrin-binding site could induce MSCs to undergo chondrogenesis in the absence of exogenous TGF-β. Within a few days of culture on the biomimetic polyacrylat ...[more]
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