Ontology highlight
ABSTRACT:
SUBMITTER: Giunti S
PROVIDER: S-EPMC3594951 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Giunti Serena S Antonelli Alessandro A Amorosi Andrea A Santarpia Libero L
International journal of endocrinology 20130221
Parafollicular C-cell-derived medullary thyroid cancer (MTC) comprises 3% to 4% of all thyroid cancers. While cytotoxic treatments have been shown to have limited efficacy, targeted molecular therapies that inhibit rearranged during transfection (RET) and other tyrosine kinase receptors that are mainly involved in angiogenesis have shown great promise in the treatment of metastatic or locally advanced MTC. Multi-tyrosine kinase inhibitors such as vandetanib, which is already approved for the tre ...[more]