Ontology highlight
ABSTRACT:
SUBMITTER: Willett R
PROVIDER: S-EPMC3595136 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Willett Rose R Kudlyk Tetyana T Pokrovskaya Irina I Schönherr Robert R Ungar Daniel D Duden Rainer R Lupashin Vladimir V
Nature communications 20130101
Vesicular tethers and SNAREs (soluble N-ethylmalemide-sensitive fusion attachment protein receptors) are two key protein components of the intracellular membrane-trafficking machinery. The conserved oligomeric Golgi (COG) complex has been implicated in the tethering of retrograde intra-Golgi vesicles. Here, using yeast two-hybrid and co-immunoprecipitation approaches, we show that three COG subunits, namely COG4, 6 and 8, are capable of interacting with defined Golgi SNAREs, namely STX5, STX6, S ...[more]