Ontology highlight
ABSTRACT:
SUBMITTER: Aghdam SY
PROVIDER: S-EPMC3595335 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Aghdam Saeed Yadranji SY Gurel Zafer Z Ghaffarieh Alireza A Sorenson Christine M CM Sheibani Nader N
Biochemical and biophysical research communications 20130204 2
The precise link between hyperglycemia and its deleterious effects on retinal and kidney microvasculature, and more specifically loss of retinal perivascular supporting cells including smooth muscle cell/pericytes (SMC/PC), in diabetes are not completely understood. We hypothesized that differential cellular proteasome activity contributes to sensitivity of PC to high glucose-mediated oxidative stress and vascular rarefaction. Here we show that retinal endothelial cells (EC) have significantly h ...[more]