Ontology highlight
ABSTRACT:
SUBMITTER: Wee LM
PROVIDER: S-EPMC3595543 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Cell 20121101 5
MicroRNAs (miRNAs) and small interfering RNAs (siRNAs) guide Argonaute proteins to silence mRNA expression. Argonaute binding alters the properties of an RNA guide, creating functional domains. We show that the domains established by Argonaute-the anchor, seed, central, 3' supplementary, and tail regions-have distinct biochemical properties that explain the differences between how animal miRNAs and siRNAs bind their targets. Extensive complementarity between an siRNA and its target slows the rat ...[more]