Ontology highlight
ABSTRACT:
SUBMITTER: Pan Y
PROVIDER: S-EPMC3595544 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Pan Yaoqian Y Balazs Louisa L Tigyi Gabor G Yue Junming J
Biochemical and biophysical research communications 20110228 3
Dicer is a RNAase III enzyme that cleaves double stranded RNA and generates small interfering RNA (siRNA) and microRNA (miRNA). The goal of this study is to examine the role of Dicer and miRNAs in vascular smooth muscle cells (VSMCs). We deleted Dicer in VSMCs of mice, which caused a developmental delay that manifested as early as embryonic day E12.5, leading to embryonic death between E14.5 and E15.5 due to extensive hemorrhage in the liver, brain, and skin. Dicer KO embryos showed dilated bloo ...[more]