Ontology highlight
ABSTRACT:
SUBMITTER: Wagschal A
PROVIDER: S-EPMC3595997 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Wagschal Alexandre A Rousset Emilie E Basavarajaiah Poornima P Contreras Xavier X Harwig Alex A Laurent-Chabalier Sabine S Nakamura Mirai M Chen Xin X Zhang Ke K Meziane Oussama O Boyer Frédéric F Parrinello Hugues H Berkhout Ben B Terzian Christophe C Benkirane Monsef M Kiernan Rosemary R
Cell 20120901 6
Transcription elongation is increasingly recognized as an important mechanism of gene regulation. Here, we show that microprocessor controls gene expression in an RNAi-independent manner. Microprocessor orchestrates the recruitment of termination factors Setx and Xrn2, and the 3'-5' exoribonuclease, Rrp6, to initiate RNAPII pausing and premature termination at the HIV-1 promoter through cleavage of the stem-loop RNA, TAR. Rrp6 further processes the cleavage product, which generates a small RNA t ...[more]