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Caspase signalling in the absence of apoptosis drives Jnk-dependent invasion.

ABSTRACT: Tumours evolve several mechanisms to evade apoptosis, yet many resected carcinomas show significantly elevated caspase activity. Moreover, caspase activity is positively correlated with tumour aggression and adverse patient outcome. These observations indicate that caspases might have a functional role in promoting tumour invasion and metastasis. Using a Drosophila model of invasion, we show that precise effector caspase activity drives cell invasion without initiating apoptosis. Affected cells express the matrix metalloprotinase Mmp1 and invade by activating Jnk. Our results link Jnk and effector caspase signalling during the invasive process and suggest that tumours under apoptotic stresses from treatment, immune surveillance or intrinsic signals might be induced further along the metastatic cascade.

SUBMITTER: Rudrapatna VA

PROVIDER: S-EPMC3596137 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature

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Caspase signalling in the absence of apoptosis drives Jnk-dependent invasion.

Rudrapatna Vivek A VA Bangi Erdem E Cagan Ross L RL

EMBO reports 20130111 2

Tumours evolve several mechanisms to evade apoptosis, yet many resected carcinomas show significantly elevated caspase activity. Moreover, caspase activity is positively correlated with tumour aggression and adverse patient outcome. These observations indicate that caspases might have a functional role in promoting tumour invasion and metastasis. Using a Drosophila model of invasion, we show that precise effector caspase activity drives cell invasion without initiating apoptosis. Affected cells ...[more]

PMID: 23306653

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