Ontology highlight
ABSTRACT:
SUBMITTER: Qiu W
PROVIDER: S-EPMC3596719 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Qiu Wen W Li Yan Y Zhou Jianbo J Zhao Chenhui C Zhang Jing J Shan Kai K Zhao Dan D Wang Yingwei Y
Journal of biomedical research 20111101 6
The proliferation of glomerular mesangial cells (GMC) and secretion of the extracellular matrix (ECM) in rat with Thy-1 nephritis (Thy-1N) resembling human mesangioproliferative glomerulonephritis have been explored for many years; however, the molecular mechanisms of GMC proliferation and ECM production remain unclear. Our previous studies have demonstrated that the thrombospondin-1 (TSP-1) gene was involved in mediating rat GMC proliferation and ECM synthesis induced by sublytic C5b-9 in vitro ...[more]