Ontology highlight
ABSTRACT:
SUBMITTER: Muller II
PROVIDER: S-EPMC3597016 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Müller Iris I II Melville David B DB Tanwar Vineeta V Rybski Witold M WM Mukherjee Amrita A Shoemaker M Benjamin MB Wang Wan-Der WD Schoenhard John A JA Roden Dan M DM Darbar Dawood D Knapik Ela W EW Hatzopoulos Antonis K AK
Disease models & mechanisms 20121207 2
Atrial fibrillation (AF) is the most common cardiac arrhythmia and carries a significant risk of stroke and heart failure. The molecular etiologies of AF are poorly understood, leaving patients with limited therapeutic options. AF has been recognized as an inherited disease in almost 30% of patient cases. However, few genetic loci have been identified and the mechanisms linking genetic variants to AF susceptibility remain unclear. By sequencing 193 probands with lone AF, we identified a Q76E var ...[more]