TNF receptors regulate vascular homeostasis in zebrafish through a caspase-8, caspase-2 and P53 apoptotic program that bypasses caspase-3.
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ABSTRACT:
SUBMITTER: Espin R
PROVIDER: S-EPMC3597020 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Publications
TNF receptors regulate vascular homeostasis in zebrafish through a caspase-8, caspase-2 and P53 apoptotic program that bypasses caspase-3.
Espín Raquel R Roca Francisco J FJ Candel Sergio S Sepulcre María P MP González-Rosa Juan M JM Alcaraz-Pérez Francisca F Meseguer José J Cayuela María L ML Mercader Nadia N Mulero Victoriano V
Disease models & mechanisms 20120906 2
Although it is known that tumor necrosis factor receptor (TNFR) signaling plays a crucial role in vascular integrity and homeostasis, the contribution of each receptor to these processes and the signaling pathway involved are still largely unknown. Here, we show that targeted gene knockdown of TNFRSF1B in zebrafish embryos results in the induction of a caspase-8, caspase-2 and P53-dependent apoptotic program in endothelial cells that bypasses caspase-3. Furthermore, the simultaneous depletion of ...[more]
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