Ontology highlight
ABSTRACT:
SUBMITTER: Wolfson J
PROVIDER: S-EPMC3597127 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Wolfson Julian J Gilbert Peter P
Biometrics 20101201 4
Given a randomized treatment Z, a clinical outcome Y, and a biomarker S measured some fixed time after Z is administered, we may be interested in addressing the surrogate endpoint problem by evaluating whether S can be used to reliably predict the effect of Z on Y. Several recent proposals for the statistical evaluation of surrogate value have been based on the framework of principal stratification. In this article, we consider two principal stratification estimands: joint risks and marginal ris ...[more]