Ontology highlight
ABSTRACT:
SUBMITTER: Sun D
PROVIDER: S-EPMC3597344 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Sun Dongxu D Novotny Michael M Bulek Katarzyna K Liu Caini C Li Xiaoxia X Hamilton Thomas T
Nature immunology 20110807 9
Interleukin 17 (IL-17) promotes the expression of chemokines and cytokines via the induction of gene transcription and post-transcriptional stabilization of mRNA. We show here that IL-17 enhanced the stability of chemokine CXCL1 mRNA and other mRNAs through a pathway that involved the adaptor Act1, the adaptors TRAF2 or TRAF5 and the splicing factor SF2 (also known as alternative splicing factor (ASF)). TRAF2 and TRAF5 were necessary for IL-17 to signal the stabilization of CXCL1 mRNA. Furthermo ...[more]