Ontology highlight
ABSTRACT:
SUBMITTER: Kreisl WC
PROVIDER: S-EPMC3597372 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Kreisl William C WC Jenko Kimberly J KJ Hines Christina S CS Lyoo Chul Hyoung CH Corona Winston W Morse Cheryl L CL Zoghbi Sami S SS Hyde Thomas T Kleinman Joel E JE Pike Victor W VW McMahon Francis J FJ Innis Robert B RB
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20120912 1
Second-generation radioligands for translocator protein (TSPO), an inflammation marker, are confounded by the codominant rs6971 polymorphism that affects binding affinity. The resulting three groups are homozygous for high-affinity state (HH), homozygous for low-affinity state (LL), or heterozygous (HL). We tested if in vitro binding to leukocytes distinguished TSPO genotypes and if genotype could affect clinical studies using the TSPO radioligand [(11)C]PBR28. In vitro binding to leukocytes and ...[more]