Lovastatin corrects excess protein synthesis and prevents epileptogenesis in a mouse model of fragile X syndrome.
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ABSTRACT:
SUBMITTER: Osterweil EK
PROVIDER: S-EPMC3597444 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Publications
Lovastatin corrects excess protein synthesis and prevents epileptogenesis in a mouse model of fragile X syndrome.
Osterweil Emily K EK Chuang Shih-Chieh SC Chubykin Alexander A AA Sidorov Michael M Bianchi Riccardo R Wong Robert K S RK Bear Mark F MF
Neuron 20130101 2
Many neuropsychiatric symptoms of fragile X syndrome (FXS) are believed to be a consequence of altered regulation of protein synthesis at synapses. We discovered that lovastatin, a drug that is widely prescribed for the treatment of high cholesterol, can correct excess hippocampal protein synthesis in the mouse model of FXS and can prevent one of the robust functional consequences of increased protein synthesis in FXS, epileptogenesis. These data suggest that lovastatin is potentially disease mo ...[more]
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