Ontology highlight
ABSTRACT:
SUBMITTER: Beckham SA
PROVIDER: S-EPMC3597671 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Beckham Simone A SA Brouwer Jason J Roth Anna A Wang Die D Sadler Anthony J AJ John Matthias M Jahn-Hofmann Kerstin K Williams Bryan R G BR Williams Bryan R G BR Wilce Jacqueline A JA Wilce Matthew C J MC
Nucleic acids research 20130115 5
The retinoic acid inducible gene-I (RIG-I)-like family of receptors is positioned at the front line of our innate cellular defence system. RIG-I detects and binds to foreign duplex RNA in the cytoplasm of both immune and non-immune cells, and initiates the induction of type I interferons and pro-inflammatory cytokines. The mechanism of RIG-I activation by double-stranded RNA (dsRNA) involves a molecular rearrangement proposed to expose the N-terminal pair of caspase activation recruitment domain ...[more]