Ontology highlight
ABSTRACT:
SUBMITTER: Hsiao C
PROVIDER: S-EPMC3597689 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Hsiao Chiaolong C Lenz Timothy K TK Peters Jessica K JK Fang Po-Yu PY Schneider Dana M DM Anderson Eric J EJ Preeprem Thanawadee T Bowman Jessica C JC O'Neill Eric B EB Lie Lively L Athavale Shreyas S SS Gossett J Jared JJ Trippe Catherine C Murray Jason J Petrov Anton S AS Wartell Roger M RM Harvey Stephen C SC Hud Nicholas V NV Williams Loren Dean LD
Nucleic acids research 20130125 5
Ancient components of the ribosome, inferred from a consensus of previous work, were constructed in silico, in vitro and in vivo. The resulting model of the ancestral ribosome presented here incorporates ∼20% of the extant 23S rRNA and fragments of five ribosomal proteins. We test hypotheses that ancestral rRNA can: (i) assume canonical 23S rRNA-like secondary structure, (ii) assume canonical tertiary structure and (iii) form native complexes with ribosomal protein fragments. Footprinting experi ...[more]