Ontology highlight
ABSTRACT:
SUBMITTER: Brooks TM
PROVIDER: S-EPMC3597803 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Brooks Teresa M TM Unterweger Daniel D Bachmann Verena V Kostiuk Benjamin B Pukatzki Stefan S
The Journal of biological chemistry 20130122 11
The type VI secretion system (T6SS) of Gram-negative bacteria has been implicated in microbial competition; however, which components serve purely structural roles, and which serve as toxic effectors remains unresolved. Here, we present evidence that VgrG-3 of the Vibrio cholerae T6SS has both structural and toxin activity. Specifically, we demonstrate that the C-terminal extension of VgrG-3 acts to degrade peptidoglycan and hypothesize that this assists in the delivery of accessory T6SS toxins ...[more]