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New echocardiographic techniques for evaluation of left atrial mechanics.

ABSTRACT: Until recently the left atrium had been subordinate to the left ventricle, but cardiologists now recognize that left atrial (LA) function is indispensable to normal circulatory performance. Transthoracic two-dimensional (2D) and Doppler echocardiography can elucidate parameters of LA function non-invasively. Yet, with the advent of 2D speckle-tracking echocardiography, we are able to detect early LA dysfunction even before structural changes occur. This is pivotal in some common disease states, such as atrial fibrillation, hypertension, and heart failure, in which LA deformation parameters can influence clinical management. However, a unique standardized technique to investigate LA deformation needs to be validated.

SUBMITTER: Todaro MC

PROVIDER: S-EPMC3598416 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature

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New echocardiographic techniques for evaluation of left atrial mechanics.

Todaro Maria Chiara MC Choudhuri Indrajit I Belohlavek Marek M Jahangir Arshad A Carerj Scipione S Oreto Lilia L Khandheria Bijoy K BK

European heart journal. Cardiovascular Imaging 20120821 12

Until recently the left atrium had been subordinate to the left ventricle, but cardiologists now recognize that left atrial (LA) function is indispensable to normal circulatory performance. Transthoracic two-dimensional (2D) and Doppler echocardiography can elucidate parameters of LA function non-invasively. Yet, with the advent of 2D speckle-tracking echocardiography, we are able to detect early LA dysfunction even before structural changes occur. This is pivotal in some common disease states, ...[more]

PMID: 22909795

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Project description:BackgroundThe aim of this article is to present an optimized acquisition and analysis protocol for the echocardiographic evaluation of left ventricle (LV) remodeling in a mouse model of myocardial infarction (MI).Methodology13 female DBA/2J mice underwent permanent occlusion of the left anterior descending (LAD) coronary artery leading to MI. Mice echocardiography was performed using a Vevo 770 (Visualsonics, Canada) before infarction, and 7, 14, 30, 60, 90 and 120 days after LAD ligation. LV systolic function was evaluated using different parameters, including the fractional area change (FAC%) computed in four high-temporal resolution B-mode short axis images taken at different ventricular levels, and in one parasternal long axis. Pulsed wave and tissue Doppler modes were used to evaluate the diastolic function and Tei Index for global cardiac function. The echocardiographic measurements of infarct size were validated histologically using collagen deposition labeled by Sirius red staining. All data was analyzed using Shapiro-Wilk and Student's t-tests.Principal findingsOur results reveal LV dilation resulting in marked remodeling an severe systolic dysfunction, starting seven days after MI (LV internal apical diameter, basal?=?2.82±0.24, 7d?=?3.49±0.42; p<0.001. End-diastolic area, basal?=?18.98±1.81, 7d?=?22.04±2.11; p<0.001). A strong statistically significant negative correlation exists between the infarct size and long-axis FAC% (r?=?-0.946; R(2)?=?0.90; p<0.05). Moreover, the measured Tei Index values confirmed significant post-infarction impairment of the global cardiac function (basal?=?0.46±0.07, 7d?=?0.55±0.08, 14 d?=?0.57±0.06, 30 d?=?0.54±0.06, 60 d?=?0.54±0.07, 90 d?=?0.57±0.08; p<0.01).Conclusions/significanceIn summary, we have performed a complete characterization of LV post-infarction remodeling in a DBA/2J mouse model of MI, using parameters adapted to the particular characteristics of the model In the future, this well characterized model will be used in both investigative and pharmacological studies that require accurate quantitative monitoring of cardiac recovery after myocardial infarction.

Dataset Information

New echocardiographic techniques for evaluation of left atrial mechanics.

Publications

New echocardiographic techniques for evaluation of left atrial mechanics.

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