Ontology highlight
ABSTRACT:
SUBMITTER: Song S
PROVIDER: S-EPMC3598594 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Developmental cell 20130301 5
Initiation of motile cell behavior in embryonic development occurs during late blastula stages when gastrulation begins. At this stage, the strong adhesion of blastomeres has to be modulated to enable dynamic behavior, similar to epithelial-to-mesenchymal transitions. We show that, in zebrafish maternal and zygotic (MZ)spg embryos mutant for the stem cell transcription factor Pou5f1/Oct4, which are severely delayed in the epiboly gastrulation movement, all blastomeres are defective in E-cadherin ...[more]