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Improved anti-proliferative effect of doxorubicin-containing polymer nanoparticles upon surface modification with cationic groups.

ABSTRACT: Polymer nanoparticles (PNPs) possessing a high density of drug payload have been successfully stabilized against aggregation in biological buffers after amine modification, which renders these PNPs positively charged. The resulting charge-stabilized PNPs retain their original narrow particle size distributions and well-defined spherical morphologies. This stabilization allows these PNPs to have an improved anti-proliferative effect on MDA-MB-231-Br human breast cancer cells compared to non-functionalized PNPs. As a non-cytotoxic control, similar surface-modified PNPs containing cholesterol in place of doxorubicin did not inhibit cell proliferation, indicating that the induced cytotoxic response was solely due to the doxorubicin release from the PNPs.

SUBMITTER: Krovi SA

PROVIDER: S-EPMC3598622 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature

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Improved anti-proliferative effect of doxorubicin-containing polymer nanoparticles upon surface modification with cationic groups.

Krovi Sai Archana SA Swindell Elden P EP O'Halloran Thomas V TV Nguyen Sonbinh T ST

Journal of materials chemistry 20121201 48

Polymer nanoparticles (PNPs) possessing a high density of drug payload have been successfully stabilized against aggregation in biological buffers after amine modification, which renders these PNPs positively charged. The resulting charge-stabilized PNPs retain their original narrow particle size distributions and well-defined spherical morphologies. This stabilization allows these PNPs to have an improved anti-proliferative effect on MDA-MB-231-Br human breast cancer cells compared to non-funct ...[more]

PMID: 23509417

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