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Next generation sequencing in cancer research and clinical application.

ABSTRACT: The wide application of next-generation sequencing (NGS), mainly through whole genome, exome and transcriptome sequencing, provides a high-resolution and global view of the cancer genome. Coupled with powerful bioinformatics tools, NGS promises to revolutionize cancer research, diagnosis and therapy. In this paper, we review the recent advances in NGS-based cancer genomic research as well as clinical application, summarize the current integrative oncogenomic projects, resources and computational algorithms, and discuss the challenge and future directions in the research and clinical application of cancer genomic sequencing.

SUBMITTER: Shyr D

PROVIDER: S-EPMC3599179 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature

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Next generation sequencing in cancer research and clinical application.

Shyr Derek D Liu Qi Q

Biological procedures online 20130213 1

The wide application of next-generation sequencing (NGS), mainly through whole genome, exome and transcriptome sequencing, provides a high-resolution and global view of the cancer genome. Coupled with powerful bioinformatics tools, NGS promises to revolutionize cancer research, diagnosis and therapy. In this paper, we review the recent advances in NGS-based cancer genomic research as well as clinical application, summarize the current integrative oncogenomic projects, resources and computational ...[more]

PMID: 23406336

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